An invertible knot is a knot that can be deformed via an ambient isotopy into itself but with the orientation reversed. A knot that is not invertible is said to be noninvertible.
Knots on ten and fewer crossing can be tested in the Wolfram Language to see if they are invertible using the command KnotData[knot, "Invertible"].
Fox (1962, Problem 10, p. 169) pointed out several knots belonging to the standard table that seemed to be noninvertible. However, no noninvertible knots were proven to exist until Trotter (1964) discovered an infinite family, the smallest of which had 15 crossings.
Three prime knots on 9 or fewer crossings are noninvertible: 
, 
, and 
(Cromwell 2004, pp. 297-299). Some noninvertible
knots can be obtained in the Wolfram Language
as KnotData["Noninvertible"].
The simplest noninvertible knot is (illustrated above) was first postulated to be
noninvertible by Fox (1962; Whitten 1972).
The following table gives the numbers of noninvertible and invertible knots of 
crossings.
| type | OEIS | counts |
| noninvertible | A052403 | 0, 0, 0, 0, 0, 0, 0, 1, 2, 33, 187, 1144, 6919, 38118, 226581, 1309875, ... |
| invertible | A052402 | 0, 0, 1, 1, 2, 3, 7, 20, 47, 132, 365, 1032, 3069, 8854, 26712, 78830, ... |
No general technique is known for determining if a knot is invertible. Burde and Zieschang (1985) give a tabulation from which it is possible to extract the noninvertible knots up to 10 crossings.
Knots." Math. Intell. 20, 33-48,
Fall 1998.Sloane, N. J. A. Sequences